Tissue Models | 3D Cell Culture Models | Life Sciences | Corning

Mimic a broad range of 3D tissue microenvironments using solid synthetic scaffold models. Because synthetic scaffolds are devoid of animal-derived materials, they are free of potential pathogens and other issues found with biologic products.

Polymers are a common choice for generating solid scaffolds of diverse size, structure, and porosity. They can be fabricated using lithography, electrospinning, bioprinting and, in the case of permeable supports, microporous membranes. For studies where endogenous factors are required to more realistically mimic the cellular in vivo environment, they can be combined with extracellular matrices (ECMs) as a coating to create effective complex matrices for 3D cell culture.

Choose the right combination of membrane type, pore size, format, and surface treatment to create a cell culture environment that more closely mimics the in vivo environment you desire.

Learn how an immortalized keratinocyte cell line, Ker-CT, is able to differentiate into organotypic skin equivalents in a 3D culture model.

Utilizing Transwell permeable supports, this protocol outlines the steps for conducting a cell invasion assay through a BME barrier with notes for conducting a chemotaxis assay.

Using the FluoroBlok insert system, Corning researchers tested anti-metastatic compounds to develop a fluorescence-based tumor cell invasion assay system.